Kaupang, Åsmund; Paulsen, Steinar Martin; Steindal, Calin Constantin; Ravna, Aina Westrheim; Sylte, Ingebrigt; Halvorsen, Trine Grønhaug; Thoresen, G. Hege; Hansen, Trond Vidar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-05)
Abstract:
Herein, we describe the synthesis, biological evaluation and molecular docking of the selective PPARb/
d antagonist (4-methyl-2-(4-(trifluoromethyl)phenyl)-N-(2-(5-(trifluoromethyl)-pyridin-2-ylsulfonyl)
ethyl)thiazole-5-carboxamide)), CC618. Results from in vitro luciferase reporter gene assays against the
three known human PPAR subtypes revealed that CC618 selectively antagonizes ...